Up to Snuff

Panoramic Radiography: Are Your Images Up to Snuff?

Hypersensitivity to pituitary snuff with miliary shadowing in the lungs.

Since 1924 powdered extracts of pig and ox pituitary glands have been used as nasal insufflations for the treatment of diabetes insipidus of mild to moderate severity, thereby avoiding the necessity for injections of pitressin tannate (Blumgart, 1922; Choay and Choay, 1924, 1928; Vidgoff, 1932; Smith, 1934). Choay and Choay (1946) and Marson (1955) have mentioned rhinorrhoea as the only side-ef...

Snuff-induced carcinogenesis: effect of snuff in rats initiated with 4-nitroquinoline N-oxide.

A canal in the lower lip to function as a reservoir for snuff was surgically created in 150 male Sprague-Dawley rats. The animals were randomized into five groups of 30 each: Group I received snuff twice a day, 5 days a wk; Group II was painted with propylene glycol (solvent control) on the hard palate 3 times a wk during 4 wk; Group III underwent painting on the hard palate with 4-nitroquinoli...

Nicotine intake by snuff users.

Blood nicotine and cotinine concentrations were measured in 27 volunteers before and after taking snuff. Within 10 minutes after snuffing blood nicotine concentrations were comparable to those obtained after the 10 minutes or so that it takes to smoke a cigarette. Nicotine intake from snuffing was related to the experience of the snuffer. In daily and occasional snuffers increases in plasma nic...

Carcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers.

Human data indicate an increased risk for cancer of the oral cavity for snuff dippers. Popular snuff products from the United States, Germany, Sweden, and Denmark were analyzed for tobacco-specific N-nitrosamines (TSNA). These compounds are formed during tobacco processing from nicotine, nornicotine, and anatabine and represent the only known carcinogens in snuff. N'-Nitrosonornicotine, a moder...